According to the latest findings, which were compiled from two separate studies, patients who responded to psilocybin-assisted therapy exhibited increased brain connectivity not just during treatment but also for up to three weeks afterward.
This "opening up" effect was linked to the participants' self-reported reductions in depression. It appears the psychedelic treats depression differently than a traditional antidepressant called escitalopram because similar changes in brain connectivity were not observed in people taking that medication.